Cefotaxime stability during in vitro microbiological testing
نویسندگان
چکیده
منابع مشابه
Cefotaxime stability during in vitro microbiological testing.
Cefotaxime is a broad-spectrum cephalosporin which is metabolized or degraded to less active or inactive metabolites by serum esterases, elevated temperatures, or a pH outside of its stability range. Cefotaxime instability during in vitro microbiological susceptibility tests may lead to an underestimation of the antibacterial activity of the compound. Cefotaxime and desacetylcefotaxime solution...
متن کاملCefotaxime, des-Cefotaxime and Ceftazidime: in vitro activity and stability to hydrolysis from TEM-derived extended spectrum β-lactamases Cefotaxime, Cefotaxime-desacetil e Ceftazidime: attività in vitro e stabilità all’idrolisi delle β-lattamasi a spettro esteso
β-lactamases production represents a determining factor in bacterial resistance to β-lactam antimicrobial agents. Over 200 enzymes have been characterized for their nucleotidic sequences and/or biochemical properties [1]. Among class A β-lactamases [2] TEM-1 is the commonest enzyme in Enterobacteriaceae. Because of wide spread use of antibiotics there has been the emergence of different variant...
متن کاملCefotaxime: in vitro activity and tentative interpretive standards for disk susceptibility testing.
Tested against 9,412 recent clinical isolates, cefotaxime exhibited 8 to 64 times greater activity against the Enterobacteriaceae than did cephalothin and two to four times greater activity against Pseudomonas aeruginosa, but only one-half to one-eighth the activity of cephalothin against staphylococci. Using 420 different clinical isolates, but with comparable minimal inhibitory concentration ...
متن کاملDiffusion disk susceptibility testing with cefotaxime.
The diffusion disk susceptibility of Staphylococcus aureus, Enterobacteriaceae, and Pseudomonas aeruginosa to cefotaxime was determined. A 30-mug disk provided data for the susceptibility of P. aeruginosa, but yielded extremely large zones of inhibition against Enterobacteriaceae. A 5-mug disk seemed to provide the most useful susceptibility data for S. aureus and Enterobacteriaceae.
متن کاملthe effect of e-64 on the developmental competence of sheep cocs during in vitro maturation
in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1987
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.31.9.1375